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Metabonomic study of the biochemical profiles of heterozygous myostatin knockout swine

Jianxiang XU,Dengke PAN,Jie ZHAO,Jianwu WANG,Xiaohong HE,Yuehui MA,Ning LI

Frontiers of Agricultural Science and Engineering 2015, Volume 2, Issue 1,   Pages 90-99 doi: 10.15302/J-FASE-2015045

Abstract: Myostatin is a transforming growth factor-β family member that normally acts to limit skeletal musclegrowth.

Keywords： myostatin     transforming growth factor-β family     skeletal muscle     metabolic disorders     chromatography     mass    

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guanosine monophosphate-specific phosphodiesterase 5 prevented cardiac fibrosis through inhibition of transforminggrowth factor β-induced Smad signaling

Wei Gong,Mengwen Yan,Junxiong Chen,Sandip Chaugai,Chen Chen,Daowen Wang

Frontiers of Medicine 2014, Volume 8, Issue 4,   Pages 445-455 doi: 10.1007/s11684-014-0378-3

Abstract: cardiac dysfunction, cardiac fibrosis and cardiac fibroblast activation but did not block TAC-induced transforminggrowth factor-β1 (TGF-β1) production and phosphorylation of Smad2/3.

Keywords： PDE5     cardiac fibrosis     TGF-β     CREB    

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Expression of integrin in hepatic fibrosis and intervention of resveratrol

Jianye WU, Chuanyong GUO, Jun LIU, Xuanfu XUAN

Frontiers of Medicine 2009, Volume 3, Issue 1,   Pages 100-107 doi: 10.1007/s11684-009-0013-x

Abstract: The expression of integrin-β1, tumor growth factor-β (TGF-β) and tissue inhibitor of metalloproteinase

Keywords： liver fibrosis     integrin-β1     resveratrol     tumor growth factor-β     tissue inhibitor of metalloproteinase-1    

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Relative expression of PTTG and bFGF in oral squamous cell carcinoma and Tca8113

Yumei DING BM , Lili CHEN MD , Bo CHENG PhD , Handong ZHANG MM ,

Frontiers of Medicine 2009, Volume 3, Issue 3,   Pages 357-362 doi: 10.1007/s11684-009-0046-1

Abstract: The purpose of this study was to investigate the expression of pituitary tumor transforming gene (PTTG) and basic fibroblast growth factor (bFGF) in oral squamous cell carcinoma (OSCC) and tongue cancer

Keywords： carcinoma     squamous cell     pituitary tumor transforming gene (PTTG) protein     basic fibroblast growth factor    

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Expression of PC-cell-derived growth factor in breast cancer

Haiping SONG MD, Lan SHI MD, Chunping LIU MD, Tao HUANG MD,

Frontiers of Medicine 2009, Volume 3, Issue 4,   Pages 426-430 doi: 10.1007/s11684-009-0085-7

Abstract: This study is mainly aimed at evaluating the expression of PC-cell-derived growth factor (PCDGF) in breast

Keywords： PC-cell-derived growth factor     breast neoplasms     clinical markers    

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The relationship between platelet-derived growth factor expression and angiogenesis/lymphangiogenesis

Guocheng LIU MD, Shouhua YANG MD, Zehua WANG MD,

Frontiers of Medicine 2009, Volume 3, Issue 4,   Pages 447-451 doi: 10.1007/s11684-009-0082-x

Abstract: This paper is aimed to examine if changes in platelet-derived growth factor (PDGF) expression at different

Keywords： cervical cancer     lymphatic vessel density     blood vessel density     platelet-derived growth factor    

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Involvement of p38 mitogen-activated protein kinase in the regulation of platelet-derived growth factor

GONG Xiaowei, WEI Jie, LI Yusheng, CHENG Weiwei, DENG Peng, JIANG Yong

Frontiers of Medicine 2007, Volume 1, Issue 3,   Pages 248-252 doi: 10.1007/s11684-007-0047-x

Abstract: the role of p38 mitogen-activated protein kinase (MAPK) in cell migration induced by platelet-derived growthfactor (PDGF).

Keywords： control     stimulation     mitogen-activated     growth factor     process    

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Fibroblast growth factor 21: a novel metabolic regulator from pharmacology to physiology

Huating Li, Jing Zhang, Weiping Jia

Frontiers of Medicine 2013, Volume 7, Issue 1,   Pages 25-30 doi: 10.1007/s11684-013-0244-8

Abstract:

Fibroblast growth factor 21 (FGF21) is a member of the fibroblast growth factor family.It actually functions as endocrine hormones but does not regulate cell growth and differentiation.Moreover, FGF21 also plays important roles in some physiological processes, such as fasting and feeding, growth

Keywords： FGF21     metabolism     pharmacology     physiology     clinical relevance    

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Mechanism of vascular endothelial growth factor on the prevention of restenosis after angioplasty

Qigong LIU, Honglian ZHOU, Yan ZENG, Shan YE, Jiani LIU, Zaiying LU

Frontiers of Medicine 2009, Volume 3, Issue 2,   Pages 177-180 doi: 10.1007/s11684-009-0021-x

Abstract: To evaluate the mechanism of vascular endothelial growth factor (VEGF) on the prevention of restenosis

Keywords： vascular endothelial growth factors     restenosis     reactive oxygen species     endothelial cells     vascular smooth    

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ACSL5, a prognostic factor in acute myeloid leukemia, modulates the activity of Wnt/-catenin signaling

Frontiers of Medicine 2023, Volume 17, Issue 4,   Pages 685-698 doi: 10.1007/s11684-022-0942-1

Abstract: Acyl-CoA synthetase long chain family member 5 (ACSL5), is a member of the acyl-CoA synthetases (ACSs) family that activates long chain fatty acids by catalyzing the synthesis of fatty acyl-CoAs.In AML cells, the ACSL5 knockdown inhibited cell growth both in vitro and in vivo.Additionally, triacsin c, a pan-ACS family inhibitor, inhibited cell growth and robustly induced cell

Keywords： acute myeloid leukemia     acyl-CoA synthetase long chain family member 5     Wnt3a     palmitoylation     ABT-199    

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An investigation on prevalent strategies for XFEM-based numerical modeling of crack growth in porous

Frontiers of Structural and Civil Engineering 2021, Volume 15, Issue 4,   Pages 914-936 doi: 10.1007/s11709-021-0750-8

Abstract: Crack growth modeling has always been one of the major challenges in fracture mechanics.Finally, the crack growth is modeled in a natural porous media (Fontainebleau sandstone).Both strategies are reliable and highly accurate in calculating the stress intensity factor, but thetests showed that the second strategy is a more accurate strategy in predicting the preferred crack growth

Keywords： numerical modeling     extended finite element method     porous media     crack growth     stress intensity factor    

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Role of nitric oxide in biological effects of vascular endothelial growth factor

Qigong LIU M D , Yan ZENG , Jiani LIU , Shan YE , Yongdong LI , Zaiying LU M D ,

Frontiers of Medicine 2009, Volume 3, Issue 3,   Pages 284-286 doi: 10.1007/s11684-009-0062-1

Abstract: To evaluate the role of nitric oxide in the biological effects of vascular endothelial growth factorvascular endothelial cells and the levels of prostaglandin (PGI), endothelin-1 (ET-1) and von Willebrand factor

Keywords： vascular endothelial growth factor     nitric oxide     N-nitro-L-arginine methyl ester     vascular endothelial    

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Early and marked up-regulation of TNF-α in acute respiratory distress syndrome after cardiopulmonary bypass

Tao Li, Nanfu Luo, Lei Du, Jin Liu, Lina Gong, Jing Zhou

Frontiers of Medicine 2012, Volume 6, Issue 3,   Pages 296-301 doi: 10.1007/s11684-012-0219-1

Abstract: release including white blood cell (WBC), neutrophils, CD11b, CD18, interleukin (IL)-8 and tumor necrosis factor

Keywords： tumor necrosis factor-α     cardiopulmonary bypass     inflammation     acute respiratory distress syndrome    

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Overcoming resistance to endocrine therapy in hormone receptor-positive human epidermal growth factor

Wenjie Zhu, Binghe Xu

Frontiers of Medicine 2021, Volume 15, Issue 2,   Pages 208-220 doi: 10.1007/s11684-020-0795-4

Abstract: New targeted therapies have been developed to overcome resistance to endocrine therapy (ET) and improve the outcome of HR /HER2 advanced breast cancer (ABC). We conducted a meta-analysis and systemic review on randomized controlled trials evaluating various targeted therapies in combination with ET in HR /HER2 ABC. PUBMED and EMBASE databases were searched for eligible trials. Hazard ratios (HRs) for progression-free survival (PFS), odds ratios (ORs) for objective response rate (ORR), clinical benefit rate (CBR), and toxicity were meta-analyzed. Twenty-six studies with data on 10 347 patients were included and pooled. The addition of cyclin-dependent kinase 4/6 inhibitors to ET significantly improved median PFS (pooled HR= 0.547, <0.001), overall survival (pooled HR= 0.755, <0.001), and tumor response rates (ORR, pooled OR= 1.478, <0.001; CBR, pooled OR= 1.201, <0.001) with manageable toxicities (pooled OR= 3.280, <0.001). The mammalian targets of rapamycin inhibitors and exemestane were not clinically beneficial for this pooled population including ET-naïve and ET-resistant patients. Moderate improvement in PFS (pooled HR= 0.686, <0.001) yet pronounced toxicities (pooled OR= 2.154, <0.001) were noted in the combination of phosphatidylinositol-4,5-bisphosphate 3-kinase inhibitors with fulvestrant. Future studies are warranted to optimize the population and the dosing sequence of these available options.

Keywords： endocrine-resistant     HR+/HER2- advanced breast cancer     randomized clinical trials     meta-analysis     targeted therapy    

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FGF23 associated bone diseases

Eryuan Liao

Frontiers of Medicine 2013, Volume 7, Issue 1,   Pages 65-80 doi: 10.1007/s11684-013-0254-6

Abstract:

Recently, fibroblast growth factor 23 (FGF23) has sparked widespread interest because of its potential

Keywords： fibroblast growth factor 23     FGF receptor     phosphate metabolism     Klotho     bone disease    

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Title Author Date Type Operation

Metabonomic study of the biochemical profiles of heterozygous myostatin knockout swine

Jianxiang XU,Dengke PAN,Jie ZHAO,Jianwu WANG,Xiaohong HE,Yuehui MA,Ning LI

Journal Article

guanosine monophosphate-specific phosphodiesterase 5 prevented cardiac fibrosis through inhibition of transforminggrowth factor β-induced Smad signaling

Wei Gong,Mengwen Yan,Junxiong Chen,Sandip Chaugai,Chen Chen,Daowen Wang

Journal Article

Expression of integrin in hepatic fibrosis and intervention of resveratrol

Jianye WU, Chuanyong GUO, Jun LIU, Xuanfu XUAN

Journal Article

Relative expression of PTTG and bFGF in oral squamous cell carcinoma and Tca8113

Yumei DING BM , Lili CHEN MD , Bo CHENG PhD , Handong ZHANG MM ,

Journal Article

Expression of PC-cell-derived growth factor in breast cancer

Haiping SONG MD, Lan SHI MD, Chunping LIU MD, Tao HUANG MD,

Journal Article

The relationship between platelet-derived growth factor expression and angiogenesis/lymphangiogenesis

Guocheng LIU MD, Shouhua YANG MD, Zehua WANG MD,

Journal Article

Involvement of p38 mitogen-activated protein kinase in the regulation of platelet-derived growth factor

GONG Xiaowei, WEI Jie, LI Yusheng, CHENG Weiwei, DENG Peng, JIANG Yong

Journal Article

Fibroblast growth factor 21: a novel metabolic regulator from pharmacology to physiology

Huating Li, Jing Zhang, Weiping Jia

Journal Article

Mechanism of vascular endothelial growth factor on the prevention of restenosis after angioplasty

Qigong LIU, Honglian ZHOU, Yan ZENG, Shan YE, Jiani LIU, Zaiying LU

Journal Article

ACSL5, a prognostic factor in acute myeloid leukemia, modulates the activity of Wnt/-catenin signaling

Journal Article

An investigation on prevalent strategies for XFEM-based numerical modeling of crack growth in porous

Journal Article

Role of nitric oxide in biological effects of vascular endothelial growth factor

Qigong LIU M D , Yan ZENG , Jiani LIU , Shan YE , Yongdong LI , Zaiying LU M D ,

Journal Article

Early and marked up-regulation of TNF-α in acute respiratory distress syndrome after cardiopulmonary bypass

Tao Li, Nanfu Luo, Lei Du, Jin Liu, Lina Gong, Jing Zhou

Journal Article

Overcoming resistance to endocrine therapy in hormone receptor-positive human epidermal growth factor

Wenjie Zhu, Binghe Xu

Journal Article

FGF23 associated bone diseases

Eryuan Liao

Journal Article